18F-Florbetapir PET in Primary Cerebral Amyloidoma

Area of Science:

• Neuropathology
• Neuroradiology
• Nuclear Medicine

Background:

• Amyloid deposition is linked to Alzheimer disease and cerebral amyloid angiopathy.
• Primary cerebral amyloidoma is a rare focal deposition that can present as a tumor-like lesion.
• Misdiagnosis as a neoplasm is a concern due to similar imaging characteristics.

Observation:

• A 54-year-old woman presented with a periventricular white matter mass on MRI.
• The mass showed T2-hyperintensity and moderate contrast enhancement.
• Pathological investigation confirmed AL (lambda) amyloidoma.

Findings:

• F-florbetapir PET/CT was utilized for diagnostic support and patient follow-up.
• The imaging findings were consistent with amyloid deposition.
• This case demonstrates the utility of F-florbetapir PET/CT in identifying amyloidoma.

Implications:

• F-florbetapir PET/CT may be a valuable tool in the diagnostic workup of suspected cerebral amyloidoma.
• This imaging modality is particularly useful in cases where biopsy is not feasible.
• Improved diagnostic accuracy can lead to appropriate management and reduce unnecessary interventions for suspected neoplasms.