Amelioration of normothermic canine liver ischemia with prostacyclin

¹Department of Surgery, University of Pittsburgh, PA.

|February 1, 1988

Abstract:

A model of hepatic ischemia was developed in dogs using a pump-driven splanchnic-to-jugular vein bypass during crossclamping of the portal triad. An LD50 was established with three hours of ischemia. PGI2 given for one hour before the ischemic insult ameliorated the ischemic injury and increased survival.

Keywords:

liver injury surgical trauma vascular occlusion canine model

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