The Auditory N1 in Schizophrenia: Comparative Analysis with a Monoaural Stimuli Paradigm

The auditory N1 component has been gaining interest as a possible biomarker in schizophrenia (SCZ). N1 to right (RE) and left ear (LE) amplitudes and latencies were assessed using a monoaural auditory oddball paradigm in 12 SCZ subjects and 15 matched healthy controls (M=40.1±8.53 and 39.4±7.73, respectively). T-student test revealed no differences between RE and LE stimulation for N1 amplitude and latency to both groups. However, there were differences in peak-to-peak N1 amplitudes between the two groups for both LE (t=-3.067; ρ=0.003) and RE (t=-2.794; ρ=0.007). These findings strengthen auditory N1 has an electrophysiological biomarker for schizophrenia.