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Updated: Oct 12, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Efficacy of echo-Doppler examination for the evaluation of renovascular disease
1First Department of Internal Medicine, Osaka University Medical School Hospital, Japan.
Insights
Noninvasive echo-Doppler velocimetry accurately diagnoses renal artery stenosis. This method, using the acceleration index (AI), shows high accuracy, sensitivity, and specificity compared to angiography.
Area of Science:
- Nephrology
- Radiology
- Medical Imaging
Background:
- Renal artery stenosis (RAS) is a significant cause of secondary hypertension and kidney disease.
- Accurate diagnosis is crucial for timely intervention and improved patient outcomes.
- Noninvasive diagnostic methods are preferred to avoid the risks associated with invasive procedures.
Purpose of the Study:
- To evaluate the diagnostic accuracy of noninvasive echo-Doppler velocimetry for renal artery stenosis.
- To compare the accuracy of echo-Doppler velocimetry with conventional angiography.
- To assess the utility of specific Doppler parameters (AI, AT, ATR) in diagnosing RAS.
Main Methods:
- A comparative study involving 40 renal arteries with suspected stenosis.
- Noninvasive diagnosis using duplex-Doppler velocimetry via a translumbar approach.
- Angiography served as the gold standard for comparison.
- Diagnosis based on acceleration index (AI), acceleration time (AT), and acceleration time ratio (ATR).
Main Results:
- High technological success rate (98%) achieved with the translumbar echo-Doppler approach.
- Echo-Doppler velocimetry demonstrated 95% accuracy, 100% sensitivity, and 93% specificity for significant RAS when using the AI criterion.
- Established normal ranges for AI (≥3.78), AT (≤0.07 s), and ATR (≤1.35) from 11 control subjects.
Conclusions:
- Noninvasive echo-Doppler velocimetry, particularly using the acceleration index, is a highly accurate method for diagnosing significant renal artery stenosis.
- This technique offers excellent sensitivity and specificity, making it a valuable screening tool.
- The translumbar approach ensures high success rates for signal acquisition.
Abstract:
The accuracy of the diagnosis of renal artery stenosis using noninvasive echo-Doppler velocimetry was compared with that of angiography in 40 renal arteries. The duplex-Doppler signals were detected through the muscle of the back (the translumbar approach). Renal artery stenosis was diagnosed by three objectively defined Doppler parameters, the acceleration index (AI), the acceleration time (AT), and the acceleration time ratio (ATR). The normal range obtained on 11 control subjects was defined as AI greater than or equal to 3.78, AT less than or equal to 0.07 s, and ATR less than or equal to 1.35. High technological success (98%) was obtained using the translumbar approach. In comparison with angiography (cases of significant stenosis), the accuracy of the echo-Doppler method using the criteria of the AI was 95%, the sensitivity was 100%, and the specificity was 93%. This noninvasive method may be one of the most accurate screening methods for diagnosing significant renal artery stenosis.
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