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Genetic variations are linked to vasomotor symptoms (VMS), commonly experienced by women. While some gene variants show associations, more research is needed to confirm these findings.

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Area of Science:

  • Genetics
  • Women's Health
  • Menopause Research

Background:

  • Vasomotor symptoms (VMS), including hot flashes and night sweats, affect approximately 70% of women.
  • The exact causes of VMS are not fully understood, but genetic factors are suspected.
  • Existing research suggests a potential genetic component influencing VMS occurrence.

Purpose of the Study:

  • To systematically review and synthesize evidence on the association between genetic variations and VMS.
  • To identify specific genes and genetic variants linked to the experience of VMS.
  • To assess the current state of research regarding the genetic etiology of VMS.

Main Methods:

  • Conducted a systematic literature search of PubMed and Embase databases.
  • Adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Included studies investigating genetic variation and VMS, excluding those on medication interventions or breast cancer treatment.

Main Results:

  • 18 studies met inclusion criteria, with sample sizes ranging from 51 to 17,695 participants.
  • Statistically significant associations were found for variants in 14 out of 26 assessed genes.
  • A genome-wide association study identified significant associations with 14 single-nucleotide variants in the tachykinin receptor 3 gene.

Conclusions:

  • Genetic variants are demonstrably associated with VMS.
  • These associations extend beyond variations in sex-steroid metabolism genes.
  • Further research is required to confirm and expand upon these genetic findings due to study limitations and heterogeneity.