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Quantifying risk factors for ischemic colitis: A nationwide, retrospective cohort study
Patrick A Twohig1, Aakash Desai2, Jacob Skeans3
1Department of Internal Medicine, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA. patwohig@gmail.com.
Summary
This study quantifies risks for ischemic colitis (IC), finding hyperlipidemia, hypertension, and heart failure significantly increase odds. Beta blockers and inflammatory diseases also elevate IC risk, aiding early patient identification.
Area of Science:
- Gastroenterology
- Epidemiology
- Clinical Medicine
Background:
- Numerous factors are linked to ischemic colitis (IC), but their relative risks are not well-defined.
- Understanding these associations is crucial for managing this condition.
Purpose of the Study:
- To quantify the risk of specific diseases and medications associated with ischemic colitis (IC).
- To identify novel risk factors for ischemic colitis.
Main Methods:
- A population-based retrospective analysis using the IBM Explorys database (1999-2018) of 57 million de-identified US patients.
- Calculation of odds ratios (OR) for IC in relation to various diseases and medications.
- Stratification of IC patients by age to analyze trends across different age groups.
Main Results:
- Hyperlipidemia showed the highest association with IC (OR 15.3), supporting atherosclerosis as a major risk factor.
- Hypertension, congestive heart failure, constipation, prior abdominal surgery, and atrial fibrillation all had OR > 10.
- Novel findings include increased IC risk associated with beta blockers (OR 9.6) and pro-inflammatory conditions like vasculitis, rheumatoid arthritis, and malignancy.
Conclusions:
- Early identification of ischemic colitis is essential to reduce patient morbidity and mortality.
- Integrating epidemiologic data into clinical algorithms can improve the rapid identification of at-risk patients.
Keywords:
Abdominal painBowel ischemiaEpidemiologyGastrointestinal bleedingHyperlipidemiaIschemic colitisLarge intestineMesenteric vesselRisk factorsMore Related Videos
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