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Updated: Dec 11, 2025

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
Published on: July 27, 2022
Structural remodelling of the heart valves extracellular matrix during embryo development
Luis Felipe Falla Zuñiga1, Yhoiss Smiht Muñoz Cerón2, Liliana Salazar3
1Medical intern, Universidad del Valle, Cali, Colombia.
Abstract:
Alterations in heart valve development represent more than 20% of congenital cardiovascular malformations. Most of the functional properties of heart valves depend on extracellular matrix. Despite its relevance, little is known about fibrillar components on developing stages. Our objective is to define histological changes on valves fibrillar components in late embryonic development of Mus musculus. We found type III collagen as the predominant fibre type in the ECM in prenatal stages followed by a switch to a type I predominance for postnatal ages. The change in fibrillar components is necessary to support the normal mechanical function of adult heart valves.
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