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Updated: Dec 11, 2025

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Atrial fibrillation after resection: a PROGRESS III study.

M J Lee1,2, D J Hawkins1, M J Bradburn3

  • 1General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|August 16, 2020
PubMed
Summary
This summary is machine-generated.

This study quantifies new-onset atrial fibrillation (AF) after colorectal cancer surgery. It aims to validate a predictive model for AF development, potentially improving patient outcomes and informing screening strategies.

Keywords:
Colorectal canceratrial fibrillationstratification

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Area of Science:

  • Cardiology
  • Oncology
  • Surgical Outcomes

Background:

  • Atrial fibrillation (AF) is a common arrhythmia impacting quality of life and increasing stroke risk.
  • Post-colonic resection, 8% of patients develop new-onset AF, affecting cancer survivorship.
  • Predicting and managing postoperative AF is crucial for patient well-being.

Purpose of the Study:

  • To accurately quantify the incidence of AF following colorectal cancer surgery.
  • To validate a predictive model for new-onset AF after colorectal cancer resection.
  • To explore novel predictors like NT-proBNP and ECG changes.

Main Methods:

  • The Atrial Fibrillation After Resection (AFAR) study will enroll 720 patients aged 65+ undergoing curative colorectal cancer surgery.
  • Cardiac rhythm assessed via 24-h Holter monitors at baseline, 30, and 90 days post-surgery.
  • ECG, EQ-5D-5L quality of life, surgical outcomes, and NT-proBNP levels will be recorded.

Main Results:

  • Study is ongoing; results pending.
  • Validation of a predictive model for postoperative AF is the primary objective.
  • Exploratory analysis will assess ECG changes and NT-proBNP for predictive value.

Conclusions:

  • Data will enable risk stratification for AF development post-colorectal cancer surgery.
  • Findings may guide targeted screening or prophylactic interventions.
  • Improved management of AF can enhance long-term quality of life and cancer survivorship.