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Related Experiment Video

Updated: Dec 11, 2025

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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What about a larger closure device?

Mehmet Cilingiroglu1, Ismail Kilic2

  • 1Department of Cardiology, Pamukkale University, Istanbul, Turkey.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|August 16, 2020
PubMed
Summary
This summary is machine-generated.

The InSeal vascular closure device (VCD) safely and effectively achieves hemostasis after transcatheter aortic valve replacement procedures. This novel device utilizes a biodegradable membrane and nitinol frame for sealing large-bore vascular access sites.

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Area of Science:

  • Cardiovascular Interventions
  • Medical Device Technology
  • Vascular Surgery

Background:

  • Increasing demand for large-bore vascular access in interventional procedures.
  • Introduction of the InSeal vascular closure device (VCD) for sealing arterial punctures.
  • The InSeal VCD employs a biodegradable membrane within a self-expanding nitinol frame.

Discussion:

  • Evaluation of the InSeal VCD's safety and efficacy in achieving hemostasis.
  • Assessment of the device's performance in the context of transcatheter aortic valve replacement (TAVR).
  • Comparison with existing methods for managing large-bore access site complications.

Key Insights:

  • The InSeal VCD demonstrates safety and effectiveness in achieving hemostasis post-TAVR.
  • Biodegradable membrane and nitinol frame contribute to successful vascular sealing.
  • Potential for improved patient outcomes and reduced complications associated with large-bore access.

Outlook:

  • Further clinical trials to validate long-term efficacy and safety.
  • Potential adoption of InSeal VCD in a wider range of large-bore interventional procedures.
  • Advancements in vascular closure technology for minimally invasive cardiac interventions.