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Hormonal Stimulation in a Gonadal Dysgenesis Mare
Gustavo Rupp Larentis1, Henrique Boll de Araujo Bastos1, Luiz Augusto Machado Centeno1
1REPROLAB - Faculdade de Veterinária, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.
Journal of Equine Veterinary Science
|August 17, 2020
Summary
This case report studied an X0 mare with a non-functional ovary. Hormonal treatment revealed a functional endometrium but no ovarian response, indicating potential for uterine function despite ovarian insufficiency.
Area of Science:
- Veterinary Medicine
- Reproductive Endocrinology
- Equine Science
Background:
- Investigated the reproductive potential of an X0 mare with ovarian dysgenesis.
- Assessed endometrial and ovarian responsiveness to exogenous hormonal therapy.
Observation:
- The X0 mare presented with a small, flaccid uterus and underdeveloped ovaries.
- Histological analysis revealed an atrophic glandular epithelium in the endometrium.
- Hormonal profiles indicated low estrogen and progesterone levels, with elevated FSH and LH.
Findings:
- Immunohistochemistry confirmed the presence of estrogen and progesterone receptors in the mare's endometrium.
- Hormonal stimulation with estradiol and progesterone induced transient endometrial changes, including edema.
- The endometrium demonstrated functional responsiveness, while ovaries remained macroscopically unchanged.
Implications:
- Suggests that the equine endometrium can respond to hormonal stimuli even in the absence of functional ovaries.
- Highlights the potential for managing uterine health in mares with ovarian insufficiency.
- Provides insights into the endocrine-dependent nature of equine uterine receptivity.
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