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Reduced mucosal prostaglandin synthesis after massive small bowel resection
J A Vanderhoof1, J H Park, C J Grandjean
1University of Nebraska Medical Center, Omaha.
The American Journal of Physiology
|March 1, 1988
Summary
Aspirin reduced prostaglandin synthesis in rat small intestines after resection. This inhibition impacted mucosal adaptation only in the distal ileum, suggesting other factors regulate adaptation proximally.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Massive small bowel resection triggers mucosal hyperplasia, a process potentially influenced by prostaglandins (PGs).
- Exogenous prostaglandin E2 (PGE2) administration is known to enhance this mucosal hyperplasia.
Purpose of the Study:
- To investigate aspirin's effect on mucosal PG synthesis post-small bowel resection.
- To determine how reduced PG synthesis impacts intestinal mucosal adaptation.
Main Methods:
- Male Sprague-Dawley rats underwent 70% jejunoileal resection or sham operation.
- Aspirin (20 mg/kg) or vehicle was administered subcutaneously every 8 hours for 12 days.
- Mucosal adaptation was assessed by measuring mucosal weight, DNA, protein, and maltase levels.
Main Results:
- Aspirin significantly reduced mucosal synthesis of PGE2, PGF2 alpha, and thromboxane B2 to 20-40% of control values.
- Mucosal adaptation was inhibited by aspirin specifically in the distal ileum.
- No significant inhibition of adaptation was observed in the duodenum, upper jejunum, or midileum.
Conclusions:
- Endogenous prostaglandins play a role in regulating distal ileum mucosal adaptation following massive small bowel resection.
- Factors other than prostaglandins appear to be more critical for adaptation in the proximal small intestine.