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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Circulating circular RNAs profiles associated with type 1 diabetes.

Shuoming Luo1,2,3, Min Deng1,2,3, Zhiguo Xie1,2,3

  • 1Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.

Diabetes/Metabolism Research and Reviews
|August 17, 2020
PubMed
Summary

Circular RNAs (circRNAs) are altered in type 1 diabetes (T1D) patients, potentially impacting disease development through miRNA interactions and coding peptides. This study identifies key circRNAs and their roles in T1D pathogenesis.

Keywords:
ceRNAscircRNAscircular RNAsnon-coding RNAtype 1 diabetes

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Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their roles in human diseases.
  • The specific involvement of circRNAs in type 1 diabetes (T1D) remains largely unexplored.

Purpose of the Study:

  • To profile circRNA expression in the peripheral blood of T1D patients.
  • To investigate the potential regulatory mechanisms and coding capabilities of identified circRNAs in T1D.

Main Methods:

  • CircRNA expression profiling using human circRNA microarray.
  • Real-time PCR for validation.
  • Bioinformatics analyses for functional prediction and interaction network construction (circRNA-miRNA-mRNA).

Main Results:

  • 93 differentially expressed circRNAs identified in T1D patients (30 upregulated, 63 downregulated).
  • Enriched functions include cellular protein metabolic process and zinc ion binding; pathways involve protein processing in the endoplasmic reticulum.
  • Several circRNAs, including hsa_circ_0072697, show potential coding capacity and involvement in T1D-related signaling pathways.

Conclusions:

  • Aberrant circRNA expression is observed in the peripheral blood of T1D patients.
  • CircRNAs may influence T1D pathogenesis through interactions with microRNAs (miRNAs) and the generation of circRNA-derived peptides.