Related Experiment Video

Updated: Dec 11, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.0K

Appraisal of Critically Ill COVID-19 Patients at a Dedicated COVID Hospital

Rakesh Bhadade1, Minal Harde2, Rosemarie deSouza3

  • 1Associate Professor, Medicine, Topiwala National Medical College and BYL Nair Ch Hospital, Mumbai, Maharashtra.

The Journal of the Association of Physicians of India
|August 17, 2020
PubMed

Insights

This study analyzed severe COVID-19 patients, identifying key factors like hyperglycemia and high inflammatory markers (IL-6, ferritin) that predict mortality. Early intervention with oxygen, antivirals, and anti-inflammatory drugs can reduce severe illness and death.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Pulmonology

Background:

  • Severe COVID-19 presents significant morbidity and mortality risks.
  • Understanding predictors of critical illness is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical patterns of severe COVID-19.
  • To identify factors associated with critical illness and mortality.
  • To inform strategies for reducing severe COVID-19 outcomes.

Main Methods:

  • Observational cohort study of critically ill COVID-19 patients.
  • Comprehensive clinical data analysis.
  • Statistical analysis including binary logistic regression.

Main Results:

  • 373 critically ill patients (68.1% male) with an 18.5% mortality rate.
  • Significant differences in age, SpO2, blood sugar, IL-6, and D-dimer between survivors and non-survivors.
  • Factors influencing mortality included hypertension, low SpO2, hyperglycemia, high inflammatory markers (LDH, ferritin), high D-dimer, low PFR, and endotracheal intubation.
  • Hydroxychloroquine, lopinavir/ritonavir, and tocilizumab were associated with recovery.

Conclusions:

  • Hallmarks of critical COVID-19 include 'Happy Hypoxia,' hyperglycemia, high inflammatory markers (IL-6, ferritin), and ARDS.
  • Early detection of severity factors and prompt, multipronged management are key.
  • Strategies include oxygen therapy, prone positioning, antivirals, corticosteroids, anticoagulants, and tocilizumab to reduce morbidity and mortality.
Abstract

More Related Videos

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

4.2K
Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.6K

Related Concept Videos

Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
638
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
135
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
677
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
858
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.4K
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
595