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Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update
Mary Jasmin Ang1, Sueun Lee1, Jong-Choon Kim1
1Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 Plus Project Team, Chonnam National University, Gwangju 61186, South Korea.
Current Neuropharmacology
|August 18, 2020
Summary
Animal models are crucial for understanding schizophrenia, a complex mental illness. This review details behavioral tasks used to assess schizophrenia-like symptoms in rodents, aiding in drug development and research.
Area of Science:
- Neuroscience
- Psychiatry
- Animal Models
Background:
- Schizophrenia affects over 21 million globally, with complex genetic and environmental factors.
- Symptoms include positive, negative, and cognitive domains.
- Animal models are vital for studying schizophrenia phenotypes.
Purpose of the Study:
- To comprehensively review behavioral tasks for measuring schizophrenia-like behaviors in rodents.
- To provide an update on recent findings in the field.
Main Methods:
- Literature search across major scientific databases (Google Scholar, PubMed, Web of Science, Scopus).
- Focus on studies published within the last 10 years.
- Inclusion of articles detailing schizophrenia-like behavioral phenotypes in animal models.
Main Results:
- Animal models and behavioral paradigms are extensively used for antipsychotic drug development.
- Behavioral tasks assess positive, negative, and cognitive symptoms to validate models against human schizophrenia.
- Validated models offer preclinical platforms for drug testing and mechanistic investigations.
Conclusions:
- Multiple behavior tests are essential for confirming and evaluating the congruence of animal models with human schizophrenia symptoms.
- Continued refinement of behavioral assessments is necessary for accurate preclinical research.
- Animal models remain indispensable tools in schizophrenia research and therapeutic development.
