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Published on: January 31, 2018
[Clinical Significance of Platelet Closure Time in Patients with Multiple Myeloma]
Ya-Nan Tang1, Hu-Jun Li1, Ya-Qi Wu1
1Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
Insights
Platelet closure time (PCT) is elevated in multiple myeloma (MM) patients and correlates with disease progression. Monitoring PCT aids in evaluating MM diagnosis and treatment effectiveness.
Area of Science:
- Hematology
- Oncology
- Clinical Diagnostics
Background:
- Multiple myeloma (MM) is a hematologic malignancy affecting plasma cells.
- Platelet function is crucial in hemostasis and can be altered in various diseases.
- Platelet closure time (PCT) is a measure of platelet function.
Purpose of the Study:
- To investigate the clinical significance of platelet closure time (PCT) in patients diagnosed with multiple myeloma (MM).
- To assess the relationship between PCT levels and MM disease stage and treatment response.
Main Methods:
- Collected peripheral blood samples from 50 newly diagnosed MM patients and 34 healthy controls.
- Measured PCT using the PFA-200 device with collagen/epinephrine (CEPI) and collagen/adenosinediphosphate (CADP) stimuli.
- Gathered clinical data including patient demographics, blood counts, biochemical markers, and MM-specific parameters like ISS stage.
Main Results:
- PCT levels were significantly higher in MM patients compared to healthy individuals.
- PCT levels increased progressively with higher International Staging System (ISS) stages in newly diagnosed MM patients.
- Following bortezomib/dexamethasone (BD) chemotherapy, PCT levels decreased significantly in patients who responded to treatment.
Conclusions:
- Platelet closure time is demonstrably abnormal in multiple myeloma patients.
- PCT levels correlate with the progression and stage of MM.
- PCT serves as a valuable biomarker for assessing diagnostic stage and therapeutic efficacy in MM management.
Objective:
To explore the clinical significance of platelet closure time (PCT) in patients with multiple myeloma (MM).
Methods:
Peripheral blood samples of 50 newly diagnosed MM patients treated in our hospital from July 2018 to November 2019 and 34 healthy persons underuent physical at the same time were collected. PCT induced by collagen/epinephrine (CEPI) and collagen/adenosinediphosphate (CADP) in peripheral blood were detected by PFA-200，and the clinical data included age, sex, leukocyte count, hemoglobin level, platelet count and level of serum creatinine, cystatin c, blood calcium, β2-microglobulin (β2-MG), bone marrow plasma cells, light chain protein, as well as the MM types, ISS stage of patients were collected.
Results:
The level of PCT in MM patients was significantly higher than that in healthy persons; the level of PCT were significantly increased with the increasing of ISS stage in newly diagnosed MM patients; After chemotherapy with bortezomib/dexamethasone (BD), the level of PCT in 15 patients who were responded to the treatment was significantly lower than those before treatment.
Conclusion:
The platelet closure time is abnormal in MM patients, moreover, relates to the progress of the disease. It has an important clinical significance for the evaluation of diagnostic stage and therapeutic efficacy evaluation of MM patients.
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