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[Correlation between Gut Microbiota and Lung Cancer].

Jun Teng1, Yanfen Zhao1, Yunning Jiang1

  • 1Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
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Gut microbiota composition differs in lung cancer patients, suggesting a link to the disease. Targeting gut microbes offers potential for personalized lung cancer diagnosis and treatment.

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Area of Science:

  • Microbiology
  • Oncology
  • Genetics

Background:

  • Gene-environment interactions are crucial in cancer development.
  • The gut microbiota, a complex microbial ecosystem, influences host health.
  • Alterations in gut microbial composition are observed in lung cancer patients.

Purpose of the Study:

  • To review the role of gut microbiota and its metabolites in lung cancer progression and treatment.
  • To explore mechanisms by which gut microbiota influences lung cancer, including metabolism, inflammation, and immune response.
  • To discuss the potential of gut microbiota as a target for personalized lung cancer therapy.

Main Methods:

  • Literature review of studies investigating the gut microbiota in lung cancer.
  • Analysis of research on microbial metabolites and their impact on cancer.
  • Synthesis of findings on gut microbiota-based diagnostic and therapeutic strategies.

Main Results:

  • Significant differences in gut microbial abundance exist between lung cancer patients and healthy individuals.
  • Gut microbiota influences lung cancer through metabolic, inflammatory, and immune pathways.
  • Emerging evidence supports the use of gut microbiota modulation in lung cancer management.

Conclusions:

  • Gut microbiota plays a significant role in lung cancer progression and treatment.
  • Targeting the gut microbiota represents a promising avenue for precise and personalized lung cancer medicine.
  • Further research into gut microbiota-host interactions is essential for advancing lung cancer care.