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Long-term omalizumab efficacy in allergic rhinitis
Carlo Cavaliere1, Elona Begvarfaj2, Cristoforo Incorvaia3
1Department of Oral and Maxillo-Facial Sciences, Sapienza University, Piazzale Aldo Moro, 5, 00185, Rome, Italy.
Long-term Omalizumab therapy effectively treated severe allergic rhinitis and asthma. This add-on treatment improved symptoms and lung function, demonstrating safety and efficacy in patients with poorly controlled conditions.
Area of Science:
- Allergy and Immunology
- Pulmonology
Background:
- Omalizumab is effective for Immunoglobulin E (IgE)-related diseases.
- Its use in severe asthma and allergic rhinitis is often off-label.
Purpose of the Study:
- To assess long-term Omalizumab effectiveness in severe allergic rhinitis and inadequately controlled severe asthma.
Main Methods:
- 11 patients with severe asthma and allergic rhinitis received Omalizumab for 36 months.
- Efficacy was measured by symptom severity, Asthma Control Test, nasal endoscopy, spirometry, and biomarkers.
Main Results:
- 10 of 11 patients completed the study.
- Significant improvements were observed in allergic rhinitis symptoms, asthma control, and lung function.
- Biomarker levels showed a reduction by study end.
Conclusions:
- Long-term Omalizumab therapy is safe and effective for severe persistent allergic rhinitis with concomitant asthma.
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