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AMP-activated protein kinase: An attractive therapeutic target for ischemia-reperfusion injury

Rong Ding1, Wei Wu2, Zhou Sun3

  • 1Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

European Journal of Pharmacology
|August 18, 2020
PubMed

Insights

AMP-activated protein kinase (AMPK) activation protects against ischemia-reperfusion (I/R) injury by regulating metabolism, oxidative stress, and inflammation. Pharmacological AMPK activation shows therapeutic potential for preventing and reducing I/R injury.

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • Ischemia-reperfusion (I/R) injury is a significant global health concern.
  • AMP-activated protein kinase (AMPK) is a critical cellular energy sensor.
  • AMPK activation is increasingly recognized for its protective roles in various organs against I/R injury.

Purpose of the Study:

  • To elucidate the mechanisms by which AMPK activation confers protection against I/R injury.
  • To review current therapeutic strategies that modulate AMPK activity for I/R injury amelioration.

Main Methods:

  • Review of preclinical studies investigating AMPK activation and I/R injury.
  • Analysis of molecular pathways involved in AMPK-mediated protection.
  • Compilation and assessment of therapeutic agents targeting AMPK for I/R injury.

Main Results:

  • AMPK activation mitigates I/R injury through modulation of energy metabolism, oxidative stress, mitochondrial function, autophagy, inflammation, and ER stress.
  • Specific therapeutic strategies like metformin and adiponectin demonstrate efficacy in preclinical models by activating AMPK.

Conclusions:

  • AMPK activation offers a multifaceted protective mechanism against I/R injury.
  • Pharmacological targeting of AMPK presents a promising therapeutic avenue for managing I/R injury.
Keywords:
AMP-Activated protein kinaseAutophagyEndoplasmic reticulum stressInflammatory responseIschemia-reperfusion injuryOxidative stress

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