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Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

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Related Experiment Video

Updated: Dec 11, 2025

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

Proliferation: Driver of HSC aging phenotypes?

Hagai Yanai¹, Isabel Beerman¹

¹Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.

Mechanisms of Ageing and Development

|August 18, 2020

Summary

Aging hematopoietic stem cells (HSCs) show impaired function, including reduced reconstitution potential and increased DNA damage. Proliferative stress may drive these age-related changes and associated pathologies.

Keywords:

Aging HSC Hematopoietic stem cell clonal expansion proliferation

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Area of Science:

Gerontology
Stem Cell Biology
Hematology

Background:

Stem cell aging is a key factor in organismal aging.
Hematopoietic stem cells (HSCs) are a well-studied model for stem cell aging.
Aging HSCs exhibit functional decline, including reduced regenerative capacity and altered differentiation.

Purpose of the Study:

To review recent discoveries on HSC aging mechanisms.
To explore the drivers of HSC aging phenotypes.
To discuss how HSC aging contributes to pathology.

Main Methods:

Review of recent scientific literature on HSC aging.
Analysis of proposed mechanisms driving HSC aging.
Discussion of the link between HSC aging and disease.

Main Results:

Aging HSCs show decreased self-renewal and altered differentiation.
Increased HSC numbers and DNA damage accumulation are observed.
Proliferative stress is implicated as a major driver of HSC aging.

Conclusions:

Understanding HSC aging is crucial for addressing age-related diseases.
Proliferative stress is a significant factor in HSC aging.
Further research is needed to fully elucidate HSC aging mechanisms and their pathological consequences.