The hangover hypothesis and the influence of moderate social drinking on mental ability

The "hangover" hypothesis proposes that there is some residual effect of low to moderate alcohol intake on the nervous system after the blood alcohol level has returned to zero. This notion has been invoked to explain the putative effects of moderate alcohol consumption on mental ability. We evaluated the hangover hypothesis by attempting to predict cognitive performance from self-reports of alcohol consumed during the week prior to testing. We found no meaningful evidence to support the notion that moderate alcohol ingestion produces a measurable toxic effect on brain function after the period of acute intoxication.