Related Experiment Video

Updated: Dec 11, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.9K

Increased heart rate with sleep disordered breathing in hypertrophic cardiomyopathy

Tomas Konecny1, Michael Khoo2, Naima Covassin3

  • 1University of Southern California, Los Angeles, California, United States of America; Mayo Clinic, Rochester, MN, United States of America.

International Journal of Cardiology
|August 18, 2020
PubMed

Insights

Sleep disordered breathing (SDB) is linked to higher heart rates (HR) in hypertrophic cardiomyopathy (HCM) patients, especially during sleep. Treating SDB may help manage HR in symptomatic HCM.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Current guidelines suggest rate-controlling medications for symptomatic hypertrophic cardiomyopathy (HCM) to improve patient symptoms.
  • The relationship between sleep disordered breathing (SDB) and elevated heart rate (HR) in HCM patients remains unclear.

Purpose of the Study:

  • To investigate the association between SDB and HR in patients diagnosed with HCM.
  • To compare HR metrics between HCM patients with and without SDB.

Main Methods:

  • Diagnosed SDB (oxygen desaturation index ≥5) in consecutive HCM patients.
  • Analyzed 24-hour Holter monitor data for mean, minimum, and maximum HR.
  • Conducted a pilot subanalysis using polysomnography (PSG) to examine heart rate variability during sleep events.

Main Results:

  • 50% of the 230 HCM patients studied had SDB.
  • HCM patients with SDB exhibited significantly higher mean HR (71 bpm vs. 67 bpm).
  • The HR difference was most pronounced during nighttime hours (10 PM to 5 AM).

Conclusions:

  • SDB is independently associated with higher mean HR in HCM patients, particularly during sleep.
  • Available SDB treatments warrant investigation as an adjunct to current HR-lowering pharmacotherapy for symptomatic HCM.
Abstract

Keywords:
Autonomic nervous systemHeart rateHypertrophic cardiomyopathySleep apneaSleep disordered breathing

More Related Videos

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice10:56

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice

Published on: August 2, 2017

10.4K
Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects06:57

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects

Published on: February 12, 2021

3.5K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
242
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
363
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
8.6K
Decreased pulse rate01:14

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
748
Increased pulse rate01:17

Increased pulse rate

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
951
Alterations in Respiration II01:30

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.3K