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Multiple pathophysiological roles of midkine in human disease
Ya-Qin Cai1, Yuncheng Lv1, Zhong-Cheng Mo1
1Hunan Province Innovative Training Base for Medical Postgraduates, Clinical Anatomy & Reproductive Medicine Application Institute, University of South China, Hengyang 421001, China; Institute of Basic Medical Sciences, Guilin Medical University, Guilin 541199, Guangxi, China.
Cytokine
|August 18, 2020
Summary
Midkine (MK) is a protein linked to various diseases. This review summarizes its diverse roles in inflammation, oxidative stress, and lipid metabolism, highlighting its impact on human health.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathophysiology
Background:
- Midkine (MK) is a protein identified as a retinoic acid-responsive gene product.
- MK is implicated in embryonic development and various diseases like cardiovascular, renal, and autoimmune conditions.
Purpose of the Study:
- To summarize the diverse pathophysiological roles of Midkine (MK) in human diseases.
- To explore MK's involvement in inflammation, oxidative stress, lipid metabolism, and immune cell regulation.
Main Methods:
- Literature review of studies on Midkine's function.
- Analysis of MK's effects on cellular processes and disease mechanisms.
Main Results:
- MK promotes inflammation by enhancing inflammatory cell recruitment and migration.
- MK contributes to oxidative stress by inducing angiotensin-converting enzyme (ACE) expression.
- MK inhibits cholesterol efflux from macrophages, impacting lipid metabolism through ABCA1 regulation.
Conclusions:
- Midkine (MK) plays a significant role in multiple pathophysiological processes.
- Understanding MK's functions is crucial for comprehending various human diseases.
- MK is a key factor in inflammation, oxidative stress, and lipid metabolism.
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