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IgA Nephropathy Associated with Trifluridine/Tipiracil: A Case Report
Geoffroy Desbuissons1,2, Liliane Ngango3, Isabelle Brochériou4
1Nephrology Department, Hôpital Privé de l'Ouest Parisien, Trappes, Ramsay Santé, Trappes, France, geodesbuissons@hotmail.fr.
Nephron
|August 18, 2020
Summary
Trifluridine/tipiracil, a cancer drug, can cause severe kidney damage. A patient developed IgA nephropathy and required dialysis after treatment, highlighting potential renal toxicity.
Area of Science:
- Nephrology
- Oncology
- Pharmacology
Background:
- Chemotherapy agents can induce various kidney diseases.
- Trifluridine/tipiracil is utilized for refractory metastatic digestive cancers.
- The renal toxicity profile of trifluridine/tipiracil remains incompletely characterized.
Observation:
- A patient undergoing trifluridine/tipiracil treatment for metastatic digestive cancer experienced adverse effects.
- The patient developed symptoms indicative of significant kidney impairment.
Findings:
- The patient was diagnosed with severe IgA nephropathy.
- Renal impairment necessitated the initiation of hemodialysis.
- The onset of IgA nephropathy occurred several weeks post-initiation of trifluridine/tipiracil therapy.
Implications:
- This case highlights a potential severe renal adverse event associated with trifluridine/tipiracil.
- Further investigation into the nephrotoxicity of trifluridine/tipiracil is warranted.
- Clinicians should monitor kidney function closely in patients receiving this treatment.
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