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Updated: Dec 11, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

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CircRNAs in anticancer drug resistance: recent advances and future potential

Tianwei Xu1, Mengwei Wang1, Lihua Jiang1

  • 1Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Jiangjiayuan road 121#, Nanjing, 210011, Jiangsu, P.R. China.

Molecular Cancer
|August 18, 2020
PubMed

Insights

Circular RNAs (circRNAs), unique RNA molecules, are crucial in cancer biology and drug resistance. This review summarizes circRNA roles in resistance to chemotherapy, targeted therapy, and immunotherapy, exploring clinical potential.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Circular RNAs (circRNAs) are a novel class of stable, non-coding RNA molecules with unique looped structures.
  • Abundant in eukaryotic cells, circRNAs regulate gene expression at transcriptional and posttranscriptional levels.
  • Emerging evidence highlights the significant role of circRNAs in various aspects of cancer biology, including tumor progression.

Purpose of the Study:

  • To provide a comprehensive review of the latest research on circRNAs in anticancer drug resistance.
  • To categorize and discuss the involvement of circRNAs in resistance to different classes of anticancer drugs.
  • To explore the potential clinical applications of circRNAs in overcoming drug resistance.

Main Methods:

  • Literature review of recent studies on circRNAs and anticancer drug resistance.
  • Classification of circRNAs based on their involvement in resistance to chemotherapy, targeted therapy, and immunotherapy.
  • Analysis of molecular mechanisms, including miRNA sponging, transcriptional regulation, and protein interactions.

Main Results:

  • CircRNAs play a critical role in regulating tumor cell proliferation and migration.
  • CircRNAs are implicated in resistance to traditional chemotherapeutic agents.
  • CircRNAs are also involved in acquired resistance to modern targeted therapies and immunotherapies.

Conclusions:

  • Circular RNAs are key players in the development of resistance to a wide spectrum of anticancer drugs.
  • Understanding circRNA mechanisms in drug resistance offers potential therapeutic strategies.
  • CircRNAs hold promise for clinical applications aimed at improving cancer treatment efficacy.
Keywords:
CancerCircular RNADrugResistance

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