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Published on: September 30, 2021
Tailoring haemophilia A prophylaxis with BAY 81-8973: A case series
Rita Carlotta Santoro1, Gaetano Giuffrida2, Filomena Daniele3
1Regional Hemophilia Center, Hemostasis and Thrombosis Unit, AOPC Pugliese-Ciaccio Hospital, Catanzaro, Italy.
Abstract:
BAY 81-8973 is an unmodified, full-length third generation recombinant factor VIII (rFVIII) which offers a more favorable pharmacokinetic (PK) profile, compared to its predecessor sucrose-formulated rFVIII (rFVIII-FS). We here report on a retrospective case series of nine patients affected by hemophilia A (HA), with variable disease severity, bleeding phenotype and comorbidities, to underline our clinical practice on prophylaxis with a recently introduced standard hall-life recombinant Factor VIII. The current case series highlights how the current clinical management of hemophilia is able to personalize treatment in several specific conditions like concomitant illnesses with thrombotic risk and allergic reactions.
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