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Updated: Dec 11, 2025

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Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting

Farshad Moradi Kashkooli1, M Soltani2, Mohammad Souri3

  • 1Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran; Department of Applied Mathematics, University of Waterloo, Waterloo, ON, Canada..

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 18, 2020
PubMed

Insights

Nanomedicine advances cancer treatment through targeted drug delivery. This research analyzes nanoparticle strategies for controlled drug release, addressing remaining challenges in cancer therapy.

Area of Science:

  • Nanomedicine and oncology
  • Biotechnology and drug delivery systems

Background:

  • Nanomedicine offers advancements in early cancer detection, targeted drug delivery, and personalized treatment.
  • Stimulus-responsive drug delivery systems aim to prevent cancer progression via controlled drug release.
  • Multifunctional targeted drug delivery systems enhance intracellular delivery.

Purpose of the Study:

  • To investigate and analyze nanoparticle-based drug delivery and release strategies for cancer treatment.
  • To address challenges in controlling drug release from nanoparticle systems.
  • To explore mathematical and clinical applications of these strategies.

Main Methods:

  • Multiscale and multidisciplinary analysis of drug delivery and release.
  • Investigation of endogenous-based and exogenous-based stimulus-responsive systems.
  • Mathematical and clinical evaluation of nanoparticle-based cancer treatment.

Main Results:

  • Identification of challenges in controlling drug release from nanoparticle systems.
  • Analysis of strategies for effective dose loading and sustained release.
  • Exploration of complex control mechanisms combining internal and external stimuli.

Conclusions:

  • Nanoparticle-based drug delivery systems show promise for cancer treatment.
  • Further research is needed to overcome challenges in drug release control.
  • Multiscale and multidisciplinary approaches are crucial for advancing nanomedicine in oncology.
Keywords:
Controlled drug releaseMathematical and computational modelingNanomedicinePersonalized medicineStimuli-responsive nanocarriersTargeted drug delivery

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