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Synthesis of interleukin-1-like activity by normal rat chondrocytes in culture
N C Rath1, A L Oronsky, S S Kerwar
1Department of Inflammation and Immunology, American Cyanamid Company, Lederle Laboratories Division, Pearl River, New York 10965.
Clinical Immunology and Immunopathology
|April 1, 1988
Abstract:
Chondrocytes prepared from the articular cartilage of young rats synthesize and secrete an interleukin-1-like activity into the medium. The physical and biochemical properties of this IL-1-like activity are similar to macrophage-derived IL-1. Immunological studies suggest that this activity is related to IL-1 alpha. Isolated chondrocytes and those grown in culture can express Ia.