Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rocky Mountain spotted fever.

C A Kamper1, K H Chessman, S J Phelps

  • 1School of Pharmacy, Samford University, Birmingham, AL.

Clinical Pharmacy
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered phenytoin pharmacokinetics in children with severe, acute traumatic brain injury.

Journal of clinical pharmacology·2001
Same author

Pharmacokinetics of naratriptan in adolescent subjects with a history of migraine.

Journal of clinical pharmacology·2001
Same author

Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus.

The Annals of pharmacotherapy·1999
Same author

Altered clearance of theophylline in children with Down syndrome: a case series.

Journal of clinical pharmacology·1999
Same author

Comparison of microparticle enzyme and fluorescence polarization immunoassays in pediatric patients not receiving digoxin.

Therapeutic drug monitoring·1998
Same author

Routine monitoring of gentamicin serum concentrations in pediatric patients with normal renal function is unnecessary.

The Annals of pharmacotherapy·1998
Same journal

Criteria for use of epoetin alfa in adult cancer and orthopedic-surgery patients.

Clinical pharmacy·1993
Same journal

Accuracy of unbound-quinidine concentration determination after ultrafiltration.

Clinical pharmacy·1993
Same journal

Modified Michaelis-Menten equation for estimating unbound-phenytoin concentrations.

Clinical pharmacy·1993
Same journal

Predicting vancomycin pharmacokinetics by using aminoglycoside pharmacokinetics.

Clinical pharmacy·1993
Same journal

Efficacy of nutritional supplements used by athletes.

Clinical pharmacy·1993
Same journal

Low-molecular-weight heparins for the treatment of deep-vein thrombosis.

Clinical pharmacy·1993
See all related articles

Rocky Mountain spotted fever is a severe tick-borne illness caused by Rickettsia rickettsii. Early recognition of nonspecific symptoms and prompt antibiotic treatment are crucial for reducing severe outcomes.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Tick-borne Illnesses

Background:

  • Rocky Mountain spotted fever (RMSF) is a severe infection transmitted by ticks.
  • High incidence rates are observed in the southeastern and south-central United States.
  • Clinical presentation can be nonspecific, leading to diagnostic delays.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, clinical features, and treatment of RMSF.
  • To highlight challenges in diagnosis and emphasize the importance of prompt treatment.
  • To provide guidance on antibiotic selection and duration for RMSF management.

Main Methods:

  • Literature review of epidemiology, pathogenesis, clinical presentation, and treatment of RMSF.
  • Discussion of diagnostic methods, including traditional serology and emerging assays.

Related Experiment Videos

  • Analysis of recommended antibiotic therapies, including chloramphenicol and tetracycline.

    • Main Results:

    • RMSF is caused by Rickettsia rickettsii and transmitted by ticks, with variable patient-reported tick exposure.
    • Initial symptoms include fever, headache, rash, and gastrointestinal issues, progressing to vasculitis and potential CNS involvement.
    • Diagnostic confirmation traditionally relies on serology, with an indirect fluorescent antibody assay becoming available.

    Conclusions:

    • Prompt diagnosis and treatment with rickettsiostatic agents (chloramphenicol or tetracycline) are essential for reducing RMSF morbidity and mortality.
    • Chloramphenicol is preferred for children under eight and patients unable to take oral medication; tetracycline is otherwise recommended.
    • Public health efforts should focus on increasing awareness of RMSF signs and symptoms and on tick bite prevention.