Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Discontinuation of mechanical ventilation.

P H Sporn1, M L Morganroth

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor.

Clinics in Chest Medicine
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prostaglandin E(2) regulates wound closure in airway epithelium.

American journal of physiology. Lung cellular and molecular physiology·2001
Same author

Keratinocyte growth factor stimulates bronchial epithelial cell proliferation in vitro and in vivo.

The American journal of physiology·1999
Same author

Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils.

Journal of immunology (Baltimore, Md. : 1950)·1999
Same author

Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor.

Prostaglandins & other lipid mediators·1998
Same author

Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure.

The American journal of physiology·1998
Same author

Cyclic stretch of airway epithelium inhibits prostanoid synthesis.

The American journal of physiology·1997

Most patients on mechanical ventilation can be weaned quickly. Difficult-to-wean patients require a systematic approach addressing underlying issues for successful ventilator withdrawal.

Area of Science:

  • Critical Care Medicine
  • Pulmonology
  • Respiratory Therapy

Background:

  • Mechanical ventilation is a life-support measure for respiratory failure.
  • Patients requiring short-term ventilation often have reversible conditions.
  • Prolonged mechanical ventilation is associated with complex patient groups.

Purpose of the Study:

  • To differentiate between short-term and long-term mechanical ventilation patient groups.
  • To identify predictors of successful discontinuation of mechanical ventilation.
  • To outline strategies for weaning patients from prolonged mechanical ventilation.

Main Methods:

  • Evaluation of spontaneous ventilatory parameters (minute ventilation, maximal voluntary ventilation, vital capacity, maximal inspiratory pressure) in short-term ventilated patients.

Related Experiment Videos

  • Assessment of systematic and comprehensive approaches for weaning difficult-to-wean patients.
  • Review of potential mechanisms inhibiting successful weaning (e.g., respiratory muscle weakness, increased work of breathing).
  • Main Results:

    • Spontaneous ventilatory parameters effectively predict weaning success in short-term ventilated patients.
    • These parameters are less reliable for predicting weaning ability in long-term ventilated patients.
    • A systematic approach optimizing pulmonary and nonpulmonary factors is crucial for successful weaning in complex cases.

    Conclusions:

    • Successful discontinuation of mechanical ventilation depends on patient group and underlying conditions.
    • Short-term ventilation weaning relies on respiratory muscle strength and ventilatory requirements.
    • Long-term ventilation weaning necessitates a comprehensive strategy addressing multiple patient factors, with no single method proving superior.