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Related Experiment Video

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Secondary Cutaneous Mantle Cell Lymphoma.

Ankita Tuknayat1,2, Reetu Kundu1,2, Monika Kucheria1,2

  • 1Drs. Tuknayat, Kucheria, and Thami are with the Department of Dermatology & Venereology.

The Journal of Clinical and Aesthetic Dermatology
|August 18, 2020
PubMed
Summary

Mantle cell lymphoma, a rare B-cell non-Hodgkin's lymphoma, can present with nonspecific symptoms and metastasize. This case highlights nasopharyngeal mantle cell lymphoma with skin metastasis, diagnosed via immunohistochemistry.

Keywords:
Lymphomamantle lymphomametastasistumor

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Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Mantle cell lymphoma (MCL) is a rare, aggressive subtype of B-cell non-Hodgkin's lymphoma.
  • MCL typically presents with a different prognosis compared to other lymphomas.
  • Nonspecific symptoms like nasal obstruction and skin plaques can mask its presence.

Observation:

  • A case of nasopharyngeal mantle cell lymphoma is presented.
  • The lymphoma demonstrated metastasis to the skin, appearing as erythematous indurated plaques.
  • Diagnosis was confirmed using immunohistochemistry.

Findings:

  • Immunohistochemistry is a reliable diagnostic tool for mantle cell lymphoma.
  • Mantle cell lymphoma can originate in the nasopharynx and spread to cutaneous sites.
  • The aggressive nature of MCL necessitates thorough staging and diagnostic evaluation.

Implications:

  • This case underscores the importance of considering rare lymphomas in the differential diagnosis of unexplained symptoms.
  • Early and accurate diagnosis using immunohistochemistry is crucial for effective management of mantle cell lymphoma.
  • Understanding metastatic patterns of MCL, including cutaneous involvement, aids in comprehensive patient care.