Related Experiment Video
Updated: Dec 11, 2025
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
An Update on the Latest Developments in Nonsteroidal Topical Therapy for Atopic Dermatitis
1Dr. Del Rosso is Research Director at JDR Dermatology Research in Las Vegas, Nevada; is with Thomas Dermatology in Las Vegas, Nevada, and is an adjunct clinical professor of dermatology at Touro University Nevada in Henderson, Nevada.
This review covers new topical treatments for atopic dermatitis, including phosphodiesterase-4 inhibitors and Janus kinase inhibitors. It highlights emerging therapies and their mechanisms of action.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Atopic dermatitis is a chronic inflammatory skin condition with significant unmet needs.
- Current topical treatments offer varying efficacy and side effect profiles.
Purpose of the Study:
- To review the latest advancements in topical treatment strategies for atopic dermatitis.
- To discuss emerging therapeutic agents and their mechanisms of action.
Main Methods:
- Literature review of recent clinical trials and research publications.
- Analysis of topical agents targeting specific molecular pathways.
Main Results:
- Several novel topical agents are in development or recently approved.
- Mechanisms discussed include phosphodiesterase-4 (PDE4) inhibition, aryl hydrocarbon receptor (AhR) activation, and Janus kinase (JAK) inhibition.
Conclusions:
- New topical therapies targeting specific pathways offer promising treatment options for atopic dermatitis.
- Further research and clinical data are crucial for optimizing the use of these agents.
More Related Videos
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
11:07Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
Related Concept Videos
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:23Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
01:22Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
01:19Clinical Applications of Epidermal Stem Cells
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...