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Updated: Dec 11, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Focus on lung cancer screening
Alfredo Tartarone1, Rosa Lerose2, Michele Aieta1
1Department of Onco-Hematology, Division of Medical Oncology, IRCCS-CROB Referral Cancer Center of Basilicata, Rionero in Vulture (PZ), Italy.
Lung cancer (LC) survival is poor due to delayed diagnosis. Low-dose computed tomography (LDCT) screening significantly reduces LC mortality in high-risk individuals, marking a crucial advance in early detection.
Area of Science:
- Oncology
- Radiology
- Public Health
Background:
- Lung cancer (LC) diagnosis is often delayed, leading to poor patient survival.
- Advanced-stage disease at diagnosis is common, highlighting the need for early detection methods.
Purpose of the Study:
- To review recent advancements in lung cancer screening.
- To discuss current challenges and open questions in lung cancer screening.
Main Methods:
- Review of randomized low-dose computed tomography (LDCT) screening trials.
- Analysis of factors influencing lung cancer patient survival and diagnosis timing.
Main Results:
- Low-dose computed tomography (LDCT) has emerged as the optimal method for lung cancer screening.
- Recent LDCT screening trials demonstrate significant reductions in lung cancer mortality among high-risk populations.
Conclusions:
- Early detection through effective lung cancer screening is critical for improving survival rates.
- Low-dose computed tomography (LDCT) screening offers a promising strategy for reducing lung cancer mortality.
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