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Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease.

Xuerong Liu1,2, Xiaogang Bai1, Jing Zhao2

  • 1Department of Endocrinology, Yanan University Affiliated Hospital, Shaanxi 716000, China.

Biomed Research International
|August 18, 2020
PubMed
Summary

The NLRC4 inflammasome rs385076 polymorphism is significantly associated with autoimmune thyroid diseases (AITDs), particularly Hashimoto's thyroiditis. This finding offers new insights into AITD pathogenesis and potential therapeutic strategies for Hashimoto's thyroiditis.

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Area of Science:

  • Immunogenetics
  • Autoimmune Diseases
  • Molecular Biology

Background:

  • NLRC4 inflammasome polymorphisms are linked to various autoimmune diseases.
  • The specific association between NLRC4 polymorphisms and autoimmune thyroid diseases (AITDs) remains unclear.
  • This study investigates the correlation between NLRC4 polymorphisms and AITDs.

Purpose of the Study:

  • To identify associations between NLRC4 gene single-nucleotide polymorphisms (SNPs) and AITDs.
  • To explore the relationship between specific NLRC4 SNPs and subtypes of AITDs, including Graves' disease and Hashimoto's thyroiditis.

Main Methods:

  • Employed Hi-SNP high-throughput genotyping technology.
  • Analyzed four NLRC4 single-nucleotide polymorphisms (SNPs).
  • Genotyped 1005 AITD patients (Graves' disease and Hashimoto's thyroiditis) and 781 healthy controls.

Main Results:

  • The NLRC4 rs385076 polymorphism showed a statistically significant association with AITDs and Hashimoto's thyroiditis in both allele and genotype distributions.
  • Significant associations were observed across allele, dominant, and homozygous models, even after adjusting for age and gender.
  • Other analyzed SNPs (rs455060, rs212704, rs675712) did not demonstrate a relationship with AITDs.

Conclusions:

  • NLRC4 rs385076 is significantly associated with Hashimoto's thyroiditis, representing a novel finding.
  • This discovery contributes to understanding the pathogenesis of AITDs.
  • It suggests potential therapeutic avenues for Hashimoto's thyroiditis.