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Updated: Dec 11, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
Circadian Rhythm and Pain: Mathematical Model based on Multiagent Simulation
Angélica T Dos Santos1, Catia M S Machado2, Diana F Adamatti2
1Universidade Federal do Rio Grande - RS - FURG, Av. Italia s/n km 08, Rio Grande, Brazil. theisangelica@gmail.com.
Abstract:
The circadian rhythm is responsible for the daily variations in metabolism, and circadian rhythm disorders have direct implications for many diseases, such as obesity and mental disorders. The regulation of sleep time is the most common example of the importance of the circadian rhythm for the functioning of the human body. In this sense, this work aims to study a mathematical and computational model based on multiagent simulation that simulates the synchronization and desynchronization of the circadian rhythm in relation to the pain variables. The results from the multiagent simulation of circadian rhythms show that in relation to pain, sleep, especially its biological rhythms, is directly affected by pain. In this way, our mathematical model was able to show that pain causes changes in the circadian rhythm and it can contribute to the medical field analysis.
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