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Management of Thrombotic Complications in COVID-19: An Update

Adrija Hajra1, Sheetal Vasundara Mathai2, Somedeb Ball3

  • 1Jacobi Medical Center/Albert Einstein College of Medicine, 1400 Pelham Pkwy S, The Bronx, NY, 10461, USA. adrija847@gmail.com.

Drugs
|August 18, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) causes coagulopathy and venous thromboembolism due to systemic inflammation. This review covers COVID-19 coagulopathy

Area of Science:

  • Medical research
  • Infectious diseases
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • COVID-19 primarily impacts the respiratory system, leading to lung injury and acute respiratory distress syndrome.
  • Systemic inflammation is the leading hypothesis for COVID-19's pathophysiology, resulting in coagulopathy.

Purpose of the Study:

  • To review the latest evidence on the pathophysiology, diagnosis, and treatment of COVID-19-associated coagulopathy.
  • To discuss prophylactic and therapeutic anticoagulation strategies for COVID-19 patients.
  • To explore post-discharge prophylaxis and novel treatments for hypercoagulability in COVID-19.

Main Methods:

  • Literature review of updated evidence on COVID-19 coagulopathy.
  • Analysis of diagnostic approaches for thrombotic complications.
  • Evaluation of current and emerging treatment strategies, including anticoagulation.

Main Results:

  • COVID-19 patients exhibit a high risk of venous thromboembolism and thrombotic complications.
  • Prophylactic anticoagulation is recommended for all hospitalized COVID-19 patients.
  • Therapeutic anticoagulation is indicated for high-risk patients or those with established venous thromboembolism.

Conclusions:

  • Coagulopathy is a significant complication of COVID-19, increasing the risk of thromboembolic events.
  • Anticoagulation strategies, including prophylactic and therapeutic, are crucial for managing COVID-19 patients.
  • Further research into novel treatments for hypercoagulability may improve patient outcomes.

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