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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jul 23, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

Transplantation for primary biliary cirrhosis.

C O Esquivel¹, D H Van Thiel, A J Demetris

¹Department of Surgery, University of Pittsburgh, Pennsylvania.

Gastroenterology

|May 1, 1988

Summary

Liver transplantation for primary biliary cirrhosis showed a 66% 5-year survival rate. Most survivors experienced good quality of life, with no demonstrated recurrence of primary biliary cirrhosis in grafts.

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Last Updated: Jul 23, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

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Heterotopic Auxiliary Whole Liver Rat Transplant Model Utilizing a Hepaticoureterostomy for Allograft Rejection Studies

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Area of Science:

Hepatology
Transplantation Immunology
Surgical Gastroenterology

Background:

Primary biliary cirrhosis (PBC) is a common reason for liver transplantation.
Understanding outcomes and complications is crucial for managing PBC patients undergoing liver transplant.

Purpose of the Study:

To present the University of Pittsburgh's experience with liver transplantation for advanced primary biliary cirrhosis.
To analyze causes of hepatic dysfunction in allografts, postoperative issues, and long-term quality of life.

Main Methods:

Retrospective review of 97 orthotopic liver transplant procedures in 76 patients with advanced PBC (March 1980 - September 1985).
Analysis of technical complications, causes of mortality, graft function, and patient survival and quality of life.

Main Results:

The transplant operation was technically feasible, with hepatic artery complications in 20% requiring grafts.
Projected 5-year survival was 66%, with most mortality in the first 6 months due to rejection and graft nonfunction.
No recurrence of PBC was observed; antimitochondrial antibodies were frequently detected post-transplant. Most survivors achieved good social and vocational rehabilitation.

Conclusions:

Liver transplantation is a viable option for advanced primary biliary cirrhosis, offering significant long-term survival and rehabilitation.
Careful management of early postoperative complications and graft function is essential for optimal outcomes.
The absence of PBC recurrence in grafts suggests successful transplantation and immune tolerance.