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Assessing Blood pressure in the Leg01:11

Assessing Blood pressure in the Leg

Proper measurement of leg blood pressure is a critical skill for healthcare providers, ensuring precise and reliable readings. When performed correctly, this procedure informs patient care and enhances the efficacy of interventions. The following text outlines step-by-step guidelines to measure blood pressure in the leg, providing clarity and ease of understanding for practitioners.
Preparation:

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A Walk with Lu-177 PSMA: How Close we Have Reached from Bench to Bedside?

Manoj Gupta1,2, G Karthikeyan3, P S Choudhury1

  • 1Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Cancer Investigation
|August 18, 2020
PubMed
Summary

Metastatic castration-resistant prostate cancer (mCRPC) requires palliative care. Theranostic endo-radioligand therapy using Lutetium 177 prostate-specific membrane antigen 617 (Lu-177 PSMA) shows promise for advanced prostate cancer management.

Keywords:
Bench to bedsideLu-177 PSMAMetastatic castration-resistant prostate cancerRadioligand therapyTheranostic

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Metastatic castration-resistant prostate cancer (mCRPC) is an advanced stage of prostate cancer characterized by resistance to standard treatments.
  • Patients with mCRPC often experience rising PSA levels, bone pain, and significant disease burden, necessitating palliative care strategies.
  • Effective disease control and improved quality of life are critical goals in managing mCRPC.

Purpose of the Study:

  • To review the current status and therapeutic potential of Lutetium 177 prostate-specific membrane antigen 617 (Lu-177 PSMA) endo-radioligand therapy for mCRPC.
  • To discuss the theranostic application of Lu-177 PSMA in the context of advanced prostate cancer treatment.
  • To explore future directions and advancements in Lu-177 PSMA therapy for mCRPC.

Main Methods:

  • Review of current literature and clinical data on Lu-177 PSMA therapy for mCRPC.
  • Analysis of the theranostic principles underlying PSMA-targeted radioligand therapy.
  • Discussion of patient selection criteria, treatment protocols, and outcomes associated with Lu-177 PSMA.

Main Results:

  • Lu-177 PSMA therapy represents a novel and promising approach for managing mCRPC.
  • The theranostic concept allows for targeted delivery of radiation to PSMA-expressing cancer cells.
  • Emerging data suggest potential benefits in disease control and palliation for selected mCRPC patients.

Conclusions:

  • Lu-177 PSMA therapy is an evolving treatment modality for metastatic castration-resistant prostate cancer.
  • Its theranostic application offers a personalized approach to targeted cancer therapy.
  • Further research and clinical trials are essential to fully establish the role and optimize the use of Lu-177 PSMA in mCRPC management.