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Resilience of Alzheimer's Disease to COVID-19

Jingwen Li1, Xi Long2, Heqing Huang3

  • 1Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Journal of Alzheimer'S Disease : JAD
|August 18, 2020
PubMed

Insights

Patients with Alzheimer's disease (AD) and COVID-19 pneumonia showed milder conditions and better prognoses than non-AD patients. Early hospitalization and access to healthcare contributed to shorter stays for AD patients with COVID-19.

Area of Science:

  • Gerontology
  • Neurology
  • Infectious Diseases

Background:

  • COVID-19 disproportionately affects seniors, particularly those with comorbidities.
  • Alzheimer's disease (AD) is a leading age-related neurodegenerative disorder requiring focused attention in the context of COVID-19.
  • The susceptibility and disease progression of COVID-19 in AD patients remain under-explored.

Purpose of the Study:

  • To investigate the clinical characteristics of COVID-19 pneumonia in patients with Alzheimer's disease.
  • To compare the clinical presentation and outcomes of COVID-19 in AD patients versus non-AD patients.

Main Methods:

  • A retrospective cohort study was conducted.
  • Clinical data from 19 AD patients with COVID-19 pneumonia were analyzed and compared with 23 non-AD COVID-19 patients.
  • Demographic, clinical, laboratory, radiological, and treatment data were collected.

Main Results:

  • Pneumonia severity was comparable between AD and non-AD COVID-19 patients.
  • AD patients exhibited earlier hospitalization, potentially due to earlier detection in care facilities or by families.
  • AD patients reported less fatigue, and a higher incidence of pericardial effusion was observed compared to non-AD patients.

Conclusions:

  • COVID-19 patients with Alzheimer's disease demonstrated milder clinical conditions and a better prognosis.
  • Adequate healthcare access facilitated resilience in AD patients, leading to shorter hospitalizations.
  • These findings highlight the importance of integrated care for elderly individuals with neurodegenerative diseases during pandemics.
Abstract

Keywords:
Alzheimer’s diseaseCOVID-19clinical characteristics

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