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Updated: Dec 11, 2025

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Genetic Polymorphisms in Sudden Sensorineural Hearing Loss: An Update.

Virginia Corazzi¹, Andrea Ciorba¹, Chiara Bianchini¹

¹ENT & Audiology Department, 9299University Hospital of Ferrara, Ferrara, Italy.

Ear, Nose, & Throat Journal

|August 18, 2020

Summary

Genetic factors may contribute to sudden sensorineural hearing loss (SSNHL). Research suggests genetic polymorphisms linked to inner ear issues like oxidative stress and vascular disease could play a role in SSNHL development.

Keywords:

genetic association genetic polymorphisms genetics idiopathic sudden sensorineural hearing loss inner ear mutation sudden sensorineural hearing loss

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Area of Science:

Genetics
Otolaryngology
Molecular Biology

Background:

Sudden sensorineural hearing loss (SSNHL) often lacks a clear cause, remaining idiopathic in many cases.
Genetic predisposition is a proposed factor in the development of SSNHL.
Understanding genetic links may illuminate SSNHL pathogenesis.

Purpose of the Study:

To explore the association between genetic polymorphisms and sudden sensorineural hearing loss (SSNHL).
To review current literature on genetic factors implicated in SSNHL.
To identify potential genetic markers for SSNHL risk and prognosis.

Main Methods:

Systematic literature review conducted across Medline/PubMed, EMBASE, and CINAHL databases.
Search performed from May 2016 to April 2020, adhering to PRISMA guidelines.
Analysis focused on studies investigating genetic polymorphisms and SSNHL.

Main Results:

Genetic susceptibility is a significant factor in SSNHL pathogenesis.
Identified polymorphisms relate to inner ear microvascular disease and endothelial dysfunction.
Other relevant polymorphisms are associated with inner ear oxidative stress and inflammation.

Conclusions:

Identifying a genetic profile for SSNHL could improve prognostic accuracy for idiopathic cases (ISSNHL).
Genetic insights may enable early prevention strategies for SSNHL.
Genetic findings could inform patients about inheritance patterns of hearing loss.