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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pediatric type 1 tympanoplasty - Does age matter?

Ali Abood1, Bartosz Torzynski1, Therese Ovesen2

  • 1Department of Oto-Rhino-Laryngology, Regional Hospital West Jutland, 7500, Holstebro, Denmark.

International Journal of Pediatric Otorhinolaryngology
|August 18, 2020
PubMed
Summary

Type 1 tympanoplasty in children effectively repairs tympanic membrane perforations and improves hearing, with success rates around 91%. Age does not impact surgical outcomes, but postoperative infection increases failure risk.

Keywords:
AgeChildrenMyringoplastyOtologyTympanoplasty

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Area of Science:

  • Otolaryngology
  • Pediatric Surgery
  • Surgical Outcomes

Background:

  • Tympanic membrane perforations negatively impact quality of life, particularly in children, often necessitating surgical intervention.
  • The optimal age for pediatric tympanoplasty remains a subject of debate in current medical literature.

Purpose of the Study:

  • To evaluate the outcomes of type 1 tympanoplasty in pediatric patients.
  • To determine the influence of patient age on the success rates of type 1 tympanoplasty.

Main Methods:

  • Retrospective cohort study of 180 patients under 18 years old undergoing type 1 tympanoplasty.
  • Analysis of tympanic membrane closure rate at six months post-surgery as the primary endpoint.
  • Assessment of air-bone gap reduction and correlation between age and surgical success.

Main Results:

  • A high surgical success rate of 91.3% was observed, with significant reduction in air-bone gap (19.8 dB to 6.9 dB).
  • No correlation was found between patient age at surgery and the rate of surgical success.
  • Postoperative infection was identified as a risk factor for surgical failure (RR 2.80, p=0.037).

Conclusions:

  • Type 1 tympanoplasty is an effective surgical procedure for children, leading to an intact tympanic membrane and improved hearing.
  • Surgical outcomes in pediatric tympanoplasty are not influenced by the patient's age.
  • Preventing and managing postoperative infections is crucial for optimizing surgical success in pediatric tympanoplasty.