Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug interactions in hypertension.

A J Wood1

  • 1Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN 37232.

Hypertension (Dallas, Tex. : 1979)
|March 1, 1988
PubMed
Summary

Drug interactions with antihypertensive medications can alter their effectiveness. These interactions, whether pharmacokinetic or pharmacodynamic, impact drug levels and responses, affecting blood pressure management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Life on the dry side: a roadmap to understanding desiccation tolerance and accelerating translational applications.

Nature communications·2025
Same author

The utility of whole-genome sequencing to identify likely transmission pairs for pathogens with slow and variable evolution.

Epidemics·2024
Same author

The readability and reliability of online information about adenoidectomy.

The Journal of laryngology and otology·2021
Same author

FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy.

Nature communications·2021
Same author

A policy of day-case sinonasal surgery is safe, well tolerated and cost-effective.

The Journal of laryngology and otology·2021
Same author

Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A.

NPJ Regenerative medicine·2019

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Drug Interactions

Background:

  • Antihypertensive agents are crucial for managing high blood pressure.
  • Interactions between co-administered drugs and antihypertensives can significantly modify treatment outcomes.
  • Understanding these interactions is vital for effective patient care.

Purpose of the Study:

  • To elucidate the mechanisms and consequences of drug interactions involving antihypertensive agents.
  • To categorize interactions based on pharmacokinetic and pharmacodynamic effects.
  • To highlight the impact on antihypertensive efficacy and patient safety.

Main Methods:

  • Review of existing literature on drug-drug interactions with antihypertensives.
  • Analysis of pharmacokinetic pathways including absorption, metabolism (enzyme inhibition/induction), and excretion.
  • Evaluation of pharmacodynamic mechanisms affecting cardiovascular and volume homeostasis.

Main Results:

  • Drug interactions can lead to either diminished or enhanced antihypertensive effects.
  • Pharmacokinetic interactions alter plasma concentrations of antihypertensive drugs.
  • Pharmacodynamic interactions modify the drug's effect at the target site, independent of concentration.

Conclusions:

  • Drug interactions represent a significant factor influencing the therapeutic response to antihypertensive medications.
  • Both pharmacokinetic and pharmacodynamic alterations contribute to changes in blood pressure control.
  • Awareness and management of these interactions are essential for optimizing antihypertensive therapy.

Related Experiment Videos