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Related Concept Videos

Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Related Experiment Video

Updated: Dec 11, 2025

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
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CoV-AbDab: the coronavirus antibody database.

Matthew I J Raybould1, Aleksandr Kovaltsuk1, Claire Marks1

  • 1Oxford Protein Informatics Group, Department of Statistics, University of Oxford, Oxford OX1 3LB, UK.

Bioinformatics (Oxford, England)
|August 18, 2020
PubMed
Summary

A new database, CoV-AbDab, consolidates information on over 1400 antibodies targeting betacoronaviruses, including SARS-CoV-2. This resource aids vaccine efficacy measurement and therapeutic development against coronaviruses.

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Area of Science:

  • Virology
  • Immunology
  • Bioinformatics

Background:

  • The emergence of SARS-CoV-2 has led to a global pandemic with significant mortality.
  • Developing vaccines and therapies requires understanding neutralizing antibodies against SARS-CoV-2.
  • Molecular characterization of antibodies is crucial for vaccine efficacy, diagnostics, and biotherapeutics.

Purpose of the Study:

  • To introduce CoV-AbDab, a novel database consolidating data on antibodies and nanobodies targeting betacoronaviruses.
  • To provide a centralized resource for researchers studying SARS-CoV-2 and related coronaviruses.
  • To facilitate the development of diagnostics and therapeutics through comprehensive antibody data.

Main Methods:

  • Compilation of published and patented antibody and nanobody data.
  • Inclusion of metadata such as antibody origin, variable domain sequence, and epitope information.
  • Cross-referencing with PDB entries and homology models.

Main Results:

  • CoV-AbDab contains data on 1402 anti-coronavirus antibodies and nanobodies as of August 5, 2020.
  • 1131 of these antibodies specifically bind to SARS-CoV-2.
  • The database includes information on cross-neutralization, antibody origin, sequences, and epitope regions.

Conclusions:

  • CoV-AbDab is the first comprehensive database of antibodies targeting SARS-CoV-2 and other betacoronaviruses.
  • The database serves as a valuable tool for researchers in vaccine development and therapeutic strategies.
  • CoV-AbDab is freely accessible, encouraging community contributions to expand its scope.