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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
645

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Electro-responsive controlled drug delivery from melanin nanoparticles.

Mariana Caldas1, Ana Cláudia Santos2, Rita Rebelo1

  • 1I3B's Research Institute on Biomaterials Biodegradables and Biomimetics, Universidade do Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associated Laboratory, Braga, Guimarães, Portugal.

International Journal of Pharmaceutics
|August 18, 2020
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Summary

Functionalized melanin nanoparticles (FMNPs) offer precise electro-responsive drug delivery. These nanoparticles efficiently load dexamethasone and release it on demand with electrical stimulation, improving therapeutic outcomes.

Keywords:
BiopolymerGreen materialMelaninNanoparticleStimuli electro-responsive controlled drug release

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Electro-responsive controlled drug delivery is crucial for on-demand therapeutics.
  • Current drug carriers often lack efficiency and stability.
  • Functionalized melanin nanoparticles (FMNPs) offer a promising alternative.

Purpose of the Study:

  • To develop an electro-responsive drug delivery system using FMNPs.
  • To precisely control the release of dexamethasone (Dex) using electrical stimulation.
  • To evaluate the efficiency and stability of the designed FMNPs.

Main Methods:

  • Synthesis of FMNPs functionalized with polydopamine and polypyrrole.
  • Characterization of FMNPs using particle size, polydispersity index, zeta-potential, and SEM.
  • Loading of dexamethasone onto FMNPs and in vitro release studies under electrical stimulation.

Main Results:

  • Optimized FMNPs exhibited a particle size of 376.77 ± 62.05 nm and a zeta-potential of -32.59 ± 3.61 mV.
  • High dexamethasone incorporation efficiency of 94.45 ± 0.63% was achieved.
  • Electrical stimulation significantly increased dexamethasone release to ca. 32% within 24 h, compared to <10% without stimuli.

Conclusions:

  • The designed FMNPs provide an effective biomaterial-based platform for electro-responsive controlled drug delivery.
  • This system demonstrates enhanced control over drug release compared to current carriers.
  • FMNPs offer improved efficiency and stability for targeted therapeutic applications.