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Differences in cancer prevalence among CHEK2 carriers identified via multi-gene panel testing

Erin G Sutcliffe1, Amy R Stettner2, Stacey A Miller2

  • 1GeneDx, 207 Perry Parkway, Gaithersburg, MD 20877, USA.

Cancer Genetics
|August 18, 2020
PubMed
Summary

CHEK2 gene variants show varied cancer risks, with some missense variants posing lower risks. Biallelic CHEK2 carriers do not face higher risks than heterozygotes, but co-occurring variants warrant management.

Keywords:
Breast cancerCHEK2Genetic testingHereditary cancer syndromes

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