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Related Experiment Video

Updated: Dec 11, 2025

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
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Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

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Perioperative neurocognitive dysfunction: thinking from the gut?

Xiaolin Xu1,2, Yimin Hu3, Enshi Yan4

  • 1Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Aging
|August 18, 2020
PubMed
Summary
This summary is machine-generated.

The gut microbiota influences brain function, impacting cognitive decline after surgery. This review explores the gut-brain axis connection in perioperative neurocognitive dysfunction, highlighting microbiota

Keywords:
brain-gut axisgut microbiotaperioperative neurocognitive dysfunctionpostoperative cognitive dysfunctionpostoperative delirium

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Area of Science:

  • Neuroscience
  • Microbiology
  • Geriatrics

Background:

  • Global population aging and medical advancements increase elderly patients undergoing surgery.
  • Perioperative neurocognitive dysfunction (PND) is a growing concern in academic and clinical settings.
  • Standardized terminology for PND, including preoperative cognitive decline, postoperative delirium, and delayed neurocognitive recovery, is now recommended.

Purpose of the Study:

  • To review current research on the gut microbiota's role in PND.
  • To explore the mechanisms linking gut microbiota to PND via the microbiota-gut-brain axis.
  • To synthesize findings on how gut microbiota alterations may contribute to PND.

Main Methods:

  • Literature review of recent studies on gut microbiota and PND.
  • Analysis of research investigating the microbiota-gut-brain axis.
  • Synthesis of evidence linking gut microbiota composition to cognitive outcomes post-surgery.

Main Results:

  • The gut microbiota is increasingly recognized for its role in neuropsychiatric conditions and central nervous system function.
  • Abnormal gut microbiota composition is implicated in the mechanisms of postoperative cognitive dysfunction and delirium.
  • Evidence suggests a significant connection between gut microbiota and PND.

Conclusions:

  • The gut microbiota plays a critical role in perioperative neurocognitive dysfunction.
  • Understanding the microbiota-gut-brain axis is key to elucidating PND mechanisms.
  • Targeting the gut microbiota may offer future therapeutic strategies for PND.