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Updated: Dec 11, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium Metathesis: A Key Step To Access a New Cyclic Tetrasubstituted Olefin Platform
Clément F Heinrich1, Didier Durand2, Jérôme Starck2
1PSL Research University, Chimie ParisTech-CNRS, Institut de Recherche de Chimie Paris, 11 rue P. et M. Curie, 75005 Paris, France.
Abstract:
An rapid and mild synthetic route for the preparation of cyclic tetrasubstituted platforms via ruthenium-catalyzed ring-closing metathesis (RCM) has been developed. This process tolerates a wide range of functionalities such as nitrogen, oxygen, sulfur, silicon, and carbon tethered groups, as well as very challenging fluorine and boron atoms (36 derivatives, up to 96%). This diversity-oriented method was further demonstrated by the postfunctionalization reactions, such as Pd-couplings, N-substitution, and reductive amination introducing a morpholine moiety.
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