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Resorbable bacterial cellulose membranes with strontium release for guided bone regeneration
Erika Patricia Chagas Gomes Luz1, Bruna Santana das Chagas2, Natália Tavares de Almeida2
1Federal University of Ceará (UFC), Department of Chemical Engineering, Bloco 709, CE 60455-760 Fortaleza, Ceará, Brazil.
Summary
Oxidized bacterial cellulose (OxBC) membranes with strontium apatite show enhanced degradation and biocompatibility for guided bone regeneration (GBR). These hybrid materials promote tissue repair and are suitable for GBR applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bacterial cellulose (BC) and hydroxyapatite (HA) hybrids are explored for guided bone regeneration (GBR).
- Degradability in physiological environments is crucial for certain GBR applications.
- Oxidized bacterial cellulose (OxBC) offers potential for enhanced material properties.
Purpose of the Study:
- To investigate oxidized bacterial cellulose (OxBC) membranes combined with strontium apatite for GBR.
- To evaluate the biodegradability, bioactivity, and physicochemical properties of novel hybrid materials.
- To assess the in vitro cytotoxicity and in vivo biocompatibility of these materials for bone regeneration.
Main Methods:
- Production and purification of BC membranes, followed by oxidation and mineralization with strontium.
- Characterization of hybrid materials (BC/HA/Sr, BC/SrAp, OxBC/HA/Sr, OxBC/SrAp) for properties and degradation.
- In vitro cytotoxicity, hemolytic assays, and in vivo histopathological evaluation in mice over 9 weeks.
Main Results:
- Hybrid materials exhibited distinct strontium release profiles; oxidation enhanced degradation under physiological conditions.
- All tested hybrid materials demonstrated bioactivity, non-cytotoxicity, and low inflammatory response in vivo.
- Oxidized membranes showed significant degradation, promoting connective tissue repair and bone regeneration.
Conclusions:
- Oxidized bacterial cellulose-derived hybrid membranes incorporating strontium apatite are bioactive and biocompatible.
- Enhanced degradation of oxidized membranes is advantageous for guided bone regeneration applications.
- These novel hybrid materials show significant potential for use in GBR therapies.
