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RETRACTED: Rehman, M.U.; Rather, I.A. Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats. <i>Plants</i> 2020, <i>9</i>, 28.

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Correction: Tiwari et al. Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats. <i>Brain Sci.</i> 2021, <i>11</i>, 288.

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Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals.

Andleeb Khan1, Sadaf Jahan2, Zuha Imtiyaz3

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

Biomedicines
|August 19, 2020
PubMed
Summary

Phytochemicals show promise in preventing and treating neurodegenerative diseases (NDs) by targeting mechanisms like oxidative stress and inflammation. While preclinical studies are effective, further clinical trials are needed to confirm their therapeutic benefits as adjuncts to conventional treatments.

Keywords:
natural productsneurodegenerative diseasesneuroprotectionphytochemicals

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Nutraceuticals

Background:

  • Increasing human lifespan has led to a rise in neurodegenerative diseases (NDs), posing significant societal burdens.
  • Despite advances in understanding ND pathogenesis, effective therapeutic options remain limited.

Purpose of the Study:

  • To review the efficacy of nutraceuticals, specifically phytochemicals, in preventing and treating various neurodegenerative diseases.
  • To critically analyze preclinical and clinical studies on phytochemicals' mechanisms of action in NDs.

Main Methods:

  • Searched PubMed, Embase, and Cochrane Library for preclinical studies on phytochemicals and NDs.
  • Utilized ClinicalTrials.gov and PubMed for clinical updates on phytochemical interventions in NDs.
  • Focused on in vivo and in vitro models to assess mechanisms of action.

Main Results:

  • Preclinical studies indicate significant efficacy of phytochemicals in various ND models.
  • Clinical studies present mixed results, suggesting potential for phytochemicals as adjuncts to conventional therapies.
  • Phytochemicals demonstrate action on key disease mechanisms including oxidative stress, inflammation, apoptosis, and gene regulation.

Conclusions:

  • Phytochemicals show promise in managing neurodegenerative diseases through multiple biological pathways.
  • Further rigorous clinical studies are essential, incorporating biomarkers and targeting specific patient populations for optimal outcomes.