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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Complement System01:27

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Drugs Used in Lower Respiratory Disorders: Overview01:17

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Related Experiment Video

Updated: Dec 11, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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The Value of Targeting Complement Components in Asthma.

Marwa M E Mohamed1, Alicia D Nicklin1, Cordula M Stover1

  • 1Department of Respiratory Sciences, University of Leicester, Leicester LE1 9HN, UK.

Medicina (Kaunas, Lithuania)
|August 19, 2020
PubMed
Summary
This summary is machine-generated.

Novel research explores targeting the complement system, a key part of the immune response, as a new treatment strategy for asthma. This approach aims to address the chronic nature of this respiratory illness.

Keywords:
asthmacomplementtreatment

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Area of Science:

  • Immunology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Asthma is a significant respiratory condition with established treatments.
  • Current asthma management is staged by endotypes and treatment response.
  • There is an ongoing search for novel therapeutic strategies for asthma.

Purpose of the Study:

  • To evaluate the potential of targeting the complement system in asthma.
  • To explore complement as a therapeutic target for this hypersensitivity reaction.
  • To discuss the chronic aspects and costs associated with asthma.

Main Methods:

  • This is a viewpoint article, not an experimental study.
  • Literature review and expert opinion on complement's role in asthma.
  • Analysis of complement pathways in the context of asthma pathophysiology.

Main Results:

  • The complement system is implicated in the hypersensitivity and chronicity of asthma.
  • Targeting complement presents a novel therapeutic avenue.
  • Understanding complement's role may lead to improved asthma management.

Conclusions:

  • Targeting the complement system offers a promising new direction for asthma therapy.
  • Further research into complement inhibition is warranted.
  • Addressing asthma's chronic nature and associated costs is crucial.