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Outcome measures for airway clearance techniques in children with chronic obstructive lung diseases: a systematic

Eline Lauwers1,2, Kris Ides3,4, Kim Van Hoorenbeeck3,4,5

  • 1Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2160 Wilrijk, Antwerp, Belgium. eline.lauwers@uantwerpen.be.

Respiratory Research
|August 19, 2020
PubMed

Insights

This review examines outcome measures for airway clearance techniques (ACTs) in children with obstructive lung diseases. A combination of methods is recommended due to discrepancies in current research to better assess ACT effectiveness.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Research Methodology

Background:

  • Airway clearance techniques (ACTs) are crucial for managing pediatric chronic obstructive lung diseases.
  • Current ACT strategies lack a strong evidence base, often relying on clinical expertise.
  • A key limitation is the absence of standardized outcome measures to evaluate ACT effectiveness.

Purpose of the Study:

  • To review all outcome measures used in pediatric research on ACTs.
  • To establish a baseline for future studies evaluating ACTs in children.
  • To guide researchers in selecting appropriate outcome measures for ACT effectiveness.

Main Methods:

  • A systematic literature search was conducted across PubMed, Web of Science, and EMBASE.
  • Search terms focused on chronic obstructive lung diseases and ACTs.
  • 49 relevant articles were selected for analysis after initial screening.

Main Results:

  • Pulmonary function tests were the most common measure (98%), followed by sputum assessment (39%) and disease exacerbation parameters (20%).
  • Other measures included oxygenation, patient-reported outcomes, exercise capacity, and imaging techniques.
  • Significant discrepancies exist between studies due to variations in design, population, and technique application.

Conclusions:

  • No single 'gold standard' outcome measure for ACTs in children was identified.
  • A combination of diverse outcome measures is recommended for a comprehensive understanding of ACT effects.
  • The review provides considerations to aid researchers in choosing optimal outcome measures for future studies.
Abstract

Keywords:
Airway clearance techniqueObstructive lung diseaseOutcome measuresPediatricsRespiratory physiotherapy

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